merck millipore,默克密理博,GF092,TRAIL Protein, Recombinant human

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merck millipore,默克密理博,GF092,TRAIL Protein, Recombinant human
产品名称：TRAIL Protein, Recombinant human
产品型号：GF092
Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.

merck millipore,默克密理博,GF092,TRAIL Protein, Recombinant human

产品介绍

merck millipore,默克密理博,GF092,TRAIL Protein, Recombinant human

重要规格表

主要应用	品种	来源	纯度
CULT	Human	E.coli	Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg of (1EU/μg) of TRAIL/Apo2L.

描述
产品目录编号	GF092
品牌系列	Chemicon®
商名	Chemicon
描述	TRAIL Protein, Recombinant human
概述	Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apoptosis, is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR transmembrane family of proteins and contain a cytoplasmic "death domain" which activates the cell's apoptotic machinery. GF092 is a 19.6 kDa protein comprising the full-length of the TNF-like extracellular domain of TRAIL.
Alternate Names	Apo2 Ligand

产品信息
演示	Sterile filtered, then lyophilized from 0.3 mg/mL in 10mM Sodium Phosphate + 110 mM NaCl.

应用
应用	Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.
主要应用	Cell Culture

生物信息
纯度	Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg of (1EU/μg) of TRAIL/Apo2L.
来源	E.coli
品种	Human
特异活性	BIOLOGICAL ACTIVITY: Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED50 for this effect is 1.0-3.0 ng/mL.
Entrez基因编号	NM_003810.2
Entrez基因汇总	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
基因符号	TRAIL TNFSF10 TL2 Apo-2L CD253 TRAIL-PEN APO2L
UniProt编号	P50591
UniProt汇总	FUNCTION: SwissProt: P50591 # Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. COFACTOR: Binds 1 zinc ion per trimer. SIZE: 281 amino acids; 32509 Da SUBUNIT: Homotrimer. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential). TISSUE SPECIFICITY: Widespread; most predominant in spleen, lung and prostate. SIMILARITY: SwissProt: P50591 ## Belongs to the tumor necrosis factor family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	The lyophilized protein may be stored at room temperature for a few weeks, but is best stored at -20°C. After a quick spin, reconstitute in sterile water to a concentration of 0.5-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 4ºC for 1 week or -20ºC for future use. Reconstituted GF092 should be stored in undiluted aliquots at -20°C for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.

储存和货运信息

存储条件

The lyophilized protein may be stored at room temperature for a few weeks, but is best stored at -20°C. After a quick spin, reconstitute in sterile water to a concentration of 0.5-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 4ºC for 1 week or -20ºC for future use. Reconstituted GF092 should be stored in undiluted aliquots at -20°C for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.