merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL154P,Anti-H-CAM Antibody, clone F10-44-2, Phycoerythrin conjugated

  • merck millipore,默克密理博,CBL154P,Anti-H-CAM Antibody, clone F10-44-2, Phycoerythrin conjugated

    产品名称：Anti-H-CAM Antibody, clone F10-44-2, Phycoerythrin conjugated
    产品型号：CBL154P
    Anti-H-CAM Antibody, clone F10-44-2, Phycoerythrin conjugated detects level of H-CAM & has been published & validated for use in FC.

    merck millipore,默克密理博,CBL154P,Anti-H-CAM Antibody, clone F10-44-2, Phycoerythrin conjugated

  • 产品介绍
  • merck millipore,默克密理博,CBL154P,Anti-H-CAM Antibody, clone F10-44-2, Phycoerythrin conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPhycoerythrinMonoclonal Antibody
    描述
    产品目录编号 CBL154P
    Replaces MAB2135E
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-H-CAM Antibody, clone F10-44-2, Phycoerythrin conjugated
    Alternate Names
    • CD44
    产品信息
    格式 Phycoerythrin
    演示 The conjugate is supplied as a 100 test vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.
    应用
    应用 Anti-H-CAM Antibody, clone F10-44-2, Phycoerythrin conjugated detects level of H-CAM & has been published & validated for use in FC.
    主要应用
    • Flow Cytometry
    应用说明 Identification of CD44 positive cells by flow cytometry and immunocytochemistry

    Studies involving T, B cell, monocyte and granulocyte binding to HEV during lymphocyte circulation and movement of leucocytes to inflammatory sites

    Studies on HCAM (homing receptor) function

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Purified human T cells
    克隆 F10-44-2
    宿主 Mouse
    特异性 The CD44 antigen is a transmembranous glycoprotein of 80 kDa, which has undergone both extensive O-linked and N-linked glycosylation. This antibody is specific for epitope 1. The CD44 antigen is present on T lymphocytes, granulocytes, red blood cells, brain and epithelial cells. There is weak expression on platelets. FUSION PARTNER: NS1 myeloma cell line
    同种型 IgG2a
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001001392.1
    • NM_000610.3
    • NM_001001389.1
    • NM_001001390.1
    • NM_001001391.1
    Entrez基因汇总 The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
    基因符号
    • HCELL
    • CD44
    • LHR
    • HUTCH-I
    • CDW44
    • CDw44
    • ECMR-III
    • Epican
    • MGC10468
    • CD44R
    • MDU2
    • PGP-1
    • CSPG8
    • Pgp1
    • IN
    • MUTCH-I
    • MDU3
    • MIC4
    • MC56
    UniProt编号
    • P16070
    UniProt汇总 FUNCTION: SwissProt: P16070 # Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
    SIZE: 742 amino acids; 81554 Da
    SUBUNIT: Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: An epithelial isoform (CD44E) is expressed by cells of epithelium and highly expressed by carcinomas. An hematopoietic isoform (CD44H) is expressed by cells of mesodermal origin. Expression is repressed in neuroblastoma cells.
    PTM: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. & N-glycosylated. & O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). & Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
    SIMILARITY: SwissProt: P16070 ## Contains 1 Link domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C for up to one year.
    包装信息
    数量 100 assays

    merck millipore,默克密理博,CBL154P,Anti-H-CAM Antibody, clone F10-44-2, Phycoerythrin conjugated

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