merck millipore,默克密理愽
  • merck millipore,默克密理博,ABN66,Anti-Cholesterol acyltransferase 1 Antibody

  • merck millipore,默克密理博,ABN66,Anti-Cholesterol acyltransferase 1 Antibody

    产品名称：Anti-Cholesterol acyltransferase 1 Antibody
    产品型号：ABN66
    This Anti-Cholesterol acyltransferase 1 Antibody is validated for use in WB, IH(P) for the detection of Cholesterol acyltransferase 1.

    merck millipore,默克密理博,ABN66,Anti-Cholesterol acyltransferase 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABN66,Anti-Cholesterol acyltransferase 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, Rhesus Macaque, ChpWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABN66
    描述 Anti-Cholesterol acyltransferase 1 Antibody
    Alternate Names
    • Cholesterol acyltransferase 1
    • Sterol O-acyltransferase 1
    • Acyl-coenzyme A:cholesterol acyltransferase 1
    • ACAT-1
    背景信息 Cholesterol acyltransferase 1 (ACAT1) is mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA and plays a significant role in ketone body metabolism. Defects in the gene encoding ACAT1 are associated with the alpha-methylacetoaceticaciduria disorder,an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. Recent studies suggests that ACAT1 may be a therapeutic target for treating certain forms of Alzeheimer's disease.
    产品信息
    格式 Affinity Purified
    控制
    • Caco-2 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Cholesterol acyltransferase 1 Antibody is validated for use in WB, IH(P) for the detection of Cholesterol acyltransferase 1.
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Cholesterol acyltransferase 1 in human adrenal gland and normal human brain tissues.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Cholesterol acyltransferase 1.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 RatHumanRhesus MacaqueChimpanzee
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rhesus Macaque, Chimpanzee, and Rat based on 100% sequence homology. Other homologies: Mouse (93% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_003092
    Entrez基因汇总 Acyl-coenzyme A:cholesterol acyltransferase (ACACT; EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988).
    基因符号
    • STAT
    • SOAT1
    • ACACT
    • ACACT1
    • ACAT
    • ACAT1
    • SOAT
    纯化方法 Affinity purified
    UniProt编号
    • P35610
    UniProt汇总 FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.

    CATALYTIC ACTIVITY: Acyl-CoA + cholesterol = CoA + cholesterol ester.

    SUBUNIT STRUCTURE: May form homo- or heterodimers.

    SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.

    INDUCTION: Highly activated by the presence of cholesterol.

    SEQUENCE SIMILARITIES: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
    产品使用声明
    质量保证 Evaluated by Western Blot in Caco-2 cell lysate.

    Western Blot Analysis: 0.05 µg/mL of this antibody detected Cholesterol acyltransferase 1 on 10 µg of Caco-2 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABN66,Anti-Cholesterol acyltransferase 1 Antibody

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