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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 B, H, R, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD31 描述 Anti-DAZL Antibody Alternate Names - SPGY-like-autosomal
- Deleted in azoospermia-like
- DAZ homolog
- DAZ-like autosomal
- Deleted in azoospermia-like 1
背景信息 DAZL (Deleted in azoospermia-like 1; SPGY-like-autosomal) is an RNA-binding protein that interacts with mRNA transcripts by its N-terminal RNA recognition motifs. It is the product of the Y-linked DAZ gene, and is found exclusively in the testes. DAZL regulates gene expression during spermatogenesis and may shuttle between the nucleus and cytoplasm during various stages of this process. It interacts with other proteins of the DAZ family via its DAZ-like domain, including DAZ, BOLL, DAZAP1, DAZAP2, and PUM2. Disruption of DAZL expression may play a role in male infertility. 产品信息 格式 Affinity Purified 控制 - Human testis tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-DAZL Antibody detects level of DAZL & has been published & validated for use in Western Blotting, IHC(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected DAZL in rat and human testis cancer tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human DAZL. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 BovineHumanRatMouse Species Reactivity Note Demonstrated to react with Human and Rat. Predicted to react with Mouse and Bovine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001342
Entrez基因汇总 The DAZ (Deleted in Azoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. 基因符号 - SPGYLA
- DAZL
- DAZH
- DAZL1
- DAZLA
纯化方法 Affinity purified UniProt编号 - Q92904
UniProt汇总 FUNCTION: RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts.
SUBUNIT STRUCTURE: Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.
TISSUE SPECIFICITY: Testis specific.
DOMAIN: The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.
SEQUENCE SIMILARITIES: Belongs to the RRM DAZ family. Contains 1 DAZ-like domain. Contains 1 RRM (RNA recognition motif) domain.产品使用声明 质量保证 Evaluated by Western Blot in human testis tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected DAZL in 10 µg of human testis tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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