merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5559,Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop

  • merck millipore,默克密理博,AB5559,Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop

    产品名称：Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop
    产品型号：AB5559
    Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop detects level of GABA A Receptor γ2 & has been published & validated for use in IP & WB.

    merck millipore,默克密理博,AB5559,Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop

  • 产品介绍
  • merck millipore,默克密理博,AB5559,Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5559
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. Approximate concentration is 0.2 mg/mL.
    应用
    应用 Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop detects level of GABA A Receptor γ2 & has been published & validated for use in IP & WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1,000

    Immunopreciptation: The antibody will immunoprecipitate 49% of all GABAA receptors in dodecylsulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 MBP fusion protein from the cytosolic loop of rat GABAA receptor gamma2 subunit.
    表位 cytoplasmic loop
    宿主 Rabbit
    特异性 GABAA receptor gamma2 subunit. Reacts with the ~44-47kDa gamma2 subunit of the GABAA receptor in rat brain membrane fractions.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_198904.1
    • NM_000816.2
    • NM_198903.1
    Entrez基因汇总 Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.
    基因符号
    • CAE2
    • GABRG2
    • ECA2
    • GEFSP3
    • GABA
    UniProt编号
    • P18507
    UniProt汇总 FUNCTION: SwissProt: P18507 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    SIZE: 467 amino acids; 54162 Da
    SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with GABARAP.
    SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
    PTM: Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability (By similarity).
    DISEASE: SwissProt: P18507 # Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2) [MIM:607681]. ECA2 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Some individuals manifest ECA2 occurring in combination with febrile seizures [MIM:121210]. A febrile seizure is defined as a convulsion event in infancy or childhood, usually occurring between 3 months and 5 years of age, associated with fever but without any evidence of intracranial infection or defined pathologic or traumatic cause. & Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3) [MIM:604233]. This autosomal dominant disorder is characterized by febrile seizures in children and afebrile seizures in adults. Penetrance is incomplete and a large intrafamilial variability of the phenotype is observed. & Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI) [MIM:607208]. SMEI is a rare disorder characterized by normal development before onset, seizures beginning in the first year of life in the form of generalized or unilateral febrile clonic seizures, secondary appearance of myoclonic seizures, and occasionally partial seizures. It is associated with ataxia, slowed psychomotor development, and mental decline.
    SIMILARITY: SwissProt: P18507 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
    MISCELLANEOUS: This subunit carries the benzodiazepine binding site.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5559,Anti-GABA A Receptor γ2 Antibody, cytoplasmic loop

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