merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3852,Anti-Cortactin Antibody, phospho-specific (Tyr421)

  • merck millipore,默克密理博,AB3852,Anti-Cortactin Antibody, phospho-specific (Tyr421)

    产品名称：Anti-Cortactin Antibody, phospho-specific (Tyr421)
    产品型号：AB3852
    Anti-Cortactin Antibody, phospho-specific (Tyr421) detects level of Cortactin & has been published & validated for use in WB.

    merck millipore,默克密理博,AB3852,Anti-Cortactin Antibody, phospho-specific (Tyr421)

  • 产品介绍
  • merck millipore,默克密理博,AB3852,Anti-Cortactin Antibody, phospho-specific (Tyr421)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3852
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cortactin Antibody, phospho-specific (Tyr421)
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in 1mg/mL in PBS with 0.05% Bronidox.
    应用
    应用 Anti-Cortactin Antibody, phospho-specific (Tyr421) detects level of Cortactin & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1-2 μg/mL

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Rabbit anti-Cortactin (Y421) polyclonal antibody was raised against a peptide corresponding to residues surrounding phosphorylated Y421of human cortactin. The immunogen peptide is available for antibody blocking studies (Cat. No. AG985)
    表位 phospho-specific (Tyr421)
    宿主 Rabbit
    特异性 Recognizes Cortactin phosphorylated on tyrosine 421. Cortactin is an 80-85 kDa actin-binding protein, which consists of a variety of protein domains. The nature and function of these domains, coupled with the presence of multiple consensus sites for phosphorylation by tyrosine and serine/threonine kinases, suggests that cortactin integrates activation of specific signaling pathways with cytoskeletal reorganization.
    品种反应性 RatHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_138565.1
    • NM_005231.2
    Entrez基因汇总 This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
    基因符号
    • FLJ34459
    • CTTN
    • EMS1
    • Amplaxin
    • 1110020L01Rik
    修改
    • Phosphorylation
    UniProt编号
    • Q14247
    UniProt汇总 FUNCTION: SwissProt: Q14247 # May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
    SIZE: 550 amino acids; 61636 Da
    SUBUNIT: Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity). Interacts with PLXDC2.
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Note=Associated with membrane ruffles and lamellipodia (By similarity).
    SIMILARITY: SwissProt: Q14247 ## Contains 7 cortactin repeats. & Contains 1 SH3 domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months after receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB3852,Anti-Cortactin Antibody, phospho-specific (Tyr421)

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