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品种反应性 主要应用 宿主 格式 抗体类型 Chp, H, Pm WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB2959 Replaces AB19025 描述 Anti-ADAM 9 Antibody, disintegrin domain Alternate Names - Metalloprotease/disintegrin/cysteine-rich protein 9
- ADAM metallopeptidase domain 9 (meltrin gamma)
- a disintegrin and metalloproteinase domain 9 (meltrin gamma)
- Cellular disintegrin-related protein
- Myeloma cell metalloproteinase
背景信息 A disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) belongs to a family of transmembrane, membrane-anchored, disintegrin-containing proteins that are involved in several biological functions such as protein ectodomain shedding, cell fusion, and cell adhesion. ADAMs contain several characteristic domains, two of which, the protease and disintegrin domains, are noted for their homology to snake venom metalloprotease. The exact function of ADAM 9 is yet unknown, however it is widely distributed, is found within keratinocytes, and is ideally placed on the cell membrane, which some studies have suggested supports a role in cell migration and motility. Alternative splicing results in two isoforms; isoform 1 is found within the cell membrane and is considered a single-pass type 1 membrane protein, while isoform 2 is secreted. Mutations in ADAM 9 expression are causal to cone-rod dystrophy type 9 or CORD9 which is characterized by visible retinal pigment deposits and loss of cone photoreceptors leading and rod degeneration, ultimately resulting in severe loss of vision. 产品信息 格式 Purified 控制 - Human chondrocyte cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide. 应用 应用 Detect ADAM 9 using this Anti-ADAM 9 Antibody, disintegrin domain validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the disintegrin domain of human ADAM 9. 表位 disintegrin domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 ChimpanzeeHumanPrimate Species Reactivity Note Demonstrated to react with human. Predicted to react with primate and chimpanzee based on 100% sequence homology.
Mouse and rat (90% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003807
Entrez基因汇总 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms. [provided by RefSeq]. 基因符号 - Meltrin-gamma
- ADAM9
- Mltng
- MDC9
- ADAM12
- MCMP
- MCMP-PEN
- MLTNG
纯化方法 Protein A purfied UniProt编号 - Q13443
UniProt汇总 FUNCTION: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.
COFACTOR: Binds 1 zinc ion per subunit (Probable).
SIZE: 819 amino acids; 90556 Da
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Widely expressed. Expressed in chondrocytes. Highest expression of isoform 2 found in liver and heart.
SIMILARITY: Contains 1 disintegrin domain. & Contains 1 EGF-like domain. & Contains 1 peptidase M12B domain.产品使用声明 质量保证 Evaluated by Western Blot in human chondrocyte cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected ADAM 9 in 10 µg of human chondrocyte cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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