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merck millipore,默克密理博,AB1968,Anti-Integrin β3 Antibody, cytoplasmic domain
产品名称：Anti-Integrin β3 Antibody, cytoplasmic domain
产品型号：AB1968
Anti-Integrin β3 Antibody, cytoplasmic domain detects level of Integrin β3 & has been published & validated for use in IP.
merck millipore,默克密理博,AB1968,Anti-Integrin β3 Antibody, cytoplasmic domain
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IP Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1968 Replaces 04-1060 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin β3 Antibody, cytoplasmic domain Alternate Names - CD61 Antigen
- Platelet Membrane Glycoprotein IIIa
产品信息 格式 Serum 演示 Whole rabbit serum. Liquid containing no preservative. 应用 应用 Anti-Integrin β3 Antibody, cytoplasmic domain detects level of Integrin β3 & has been published & validated for use in IP. 主要应用 - Immunoprecipitation
应用说明 Immunoprecipitation
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to the cytoplasmic domain of human integrin beta 3 conjugated to thyroglobulin with gluteraldehyde. 表位 cytoplasmic domain 宿主 Rabbit 特异性 Integrin beta3. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000212.2
Entrez基因汇总 The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. 基因符号 - GPIIIa
- ITGB3
- GP3A
- CD61
UniProt编号 - P05106
UniProt汇总 FUNCTION: SwissProt: P05106 # Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 788 amino acids; 87058 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
PTM: Phosphorylated on tyrosine residues in response to thrombin- induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. SHC binding also occurs when Tyr-785 alone is phosphorylated.
DISEASE: SwissProt: P05106 # Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.
SIMILARITY: SwissProt: P05106 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20ºC in undiluted aliquots for up to twelve months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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