merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1585,Anti-Dopamine β Hydroxylase Antibody

  • merck millipore,默克密理博,AB1585,Anti-Dopamine β Hydroxylase Antibody

    产品名称：Anti-Dopamine β Hydroxylase Antibody
    产品型号：AB1585
    Detect Dopamine β Hydroxylase using this Anti-Dopamine β Hydroxylase Antibody validated for use in IH, FUNC, RIA & WB.

    merck millipore,默克密理博,AB1585,Anti-Dopamine β Hydroxylase Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB1585,Anti-Dopamine β Hydroxylase Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Fe, B, Gp, H, R, RbWB, IHCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB1585
    Replaces AB145
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Dopamine β Hydroxylase Antibody
    Alternate Names
    • Dopamine beta-monooxygenase
    • DBH
    产品信息
    格式 Serum
    控制
    • Brain (Striatum/Substantia Nigra)
    演示 Rabbit Serum. Lyophilized, no preservatives. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material.
    应用
    应用 Detect Dopamine β Hydroxylase using this Anti-Dopamine β Hydroxylase Antibody validated for use in IH, FUNC, RIA & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry: 1:2,000 on rabbit and guinea pig using an ABC detection method.

    Western blot

    RIA

    Inhibitory studies in vivo and in vitro.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Native enzyme from bovine adrenal glands.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Dopamine beta hydroxylase. AB1585 reacts with a single band on Western blots of bovine adrenal homogenates and stains only cells known to contain DBH, such as sympathetic neurons, adrenal medullary cells and central adrenergic neurons. Staining is abolished by preincubation with enzyme.
    品种反应性 FelineBovineGuinea PigHumanRatRabbit
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000787.3
    Entrez基因汇总 The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
    基因符号
    • EC 1.14.17.1 [Contains: Soluble dopamine beta-hydroxylase].
    • DBH
    • DBM
    纯化方法 Unpurified
    UniProt编号
    • P09172
    UniProt汇总 FUNCTION: SwissProt: P09172 # Conversion of dopamine to noradrenaline.
    COFACTOR: Binds 1 PQQ per subunit. & Binds 2 copper ions per subunit.
    SIZE: 617 amino acids; 69065 Da
    SUBUNIT: Homotetramer composed of two non-covalently bound disulfide-linked dimers.
    SUBCELLULAR LOCATION: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. & Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential).
    DISEASE: SwissProt: P09172 # Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
    SIMILARITY: SwissProt: P09172 ## Belongs to the copper type II ascorbate-dependent monooxygenase family. & Contains 1 DOMON domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20 to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20 to -70°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles. Glycerol can be added 1:1 for additional stability.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB1585,Anti-Dopamine β Hydroxylase Antibody

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