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品种反应性 主要应用 宿主 格式 抗体类型 R WB M Serum Polyclonal Antibody 描述 产品目录编号 AB15664 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-NUDEL Antibody Alternate Names - NudE nuclear distribution gene E homolog (A. nidulans)-like 1
- NDEL1
背景信息 NudE nuclear distribution gene E homolog (A. nidulans)-like 1 (NUDEL), also known as NDEL1, is a human gene. This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. This protein plays a role in nervous system development and is linked to LIS-1, the disease gene for a form of lissencephaly, a disorder of cortical development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. 产品信息 格式 Serum 控制 - brain lysate
演示 Serum with 0.05% NaN3 应用 应用 This Anti-NUDEL Antibody is validated for use in WB for the detection of NUDEL. 主要应用 - Western Blotting
应用说明 Western Blot: 1:5000L 生物信息 免疫原品种 Synthetic Linear Peptide. 宿主 Mouse 特异性 Recognizes rat NUDEL 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - 170847
Entrez基因汇总 a LIS1-interacting protein [RGD] 基因符号 - Ndel1
- NUDE2
- Nudel
UniProt编号 - Q78PB6
UniProt汇总 FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL (By similarity).
SUBUNIT: Self-associates. Interacts with DISC1, dynactin, tubulin gamma, KATNA1, KATNB1, microtubules, PCM1, PCNT, and YWHAE. Interacts directly with NEFL and indirectly with NEFH (By similarity). Interacts with dynein and PAFAH1B1.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Centrosome. Spindle. Note=Localizes to the mitotic spindle and to the to the microtubules of the manchette in elongated spermatids (By similarity). Localizes to the interphase centrosome. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes.
PTM: Phosphorylated in mitosis. Can be phosphorylated by CDC2, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE (By similarity).
SIMILARITY: Belongs to the nudE family.
CAUTION: Was originally (Uniprot Ref.4) thought to function as an oligopeptidase (NUDEL-oligopeptidase or endooligopeptidase A) which could regulate peptide levels relevant to brain function.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. 包装信息 数量 100 µL
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