merck millipore,默克密理博,AB10531,Anti-NR2A Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, M	WB	Rb	Serum	Polyclonal Antibody

描述
产品目录编号	AB10531
描述	Anti-NR2A Antibody
Alternate Names	glutamate receptor, ionotropic, N-methyl D-aspartate 2A, NMDA N-methyl D-aspartate receptor subtype 2A N-methyl-D-aspartate receptor channel, subunit epsilon-1 N-methyl-D-aspartate receptor subunit 2A NMDA receptor subtype 2A
背景信息	NR2 or glutamate receptor, ionotropic, N-methyl D-aspartate 2 (NMDA2; NMDAR2) along with the NR1 subunit forms a heterodimer that make up the NMDA receptor. By alternative splicing there are various isoforms of NR2 classified as NR2A through D. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. The NR1 subunit binds glycine while the NR2 subunit binds glutamine for activation. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory.

产品信息
格式	Serum
控制	Mouse brain tissue lysate
演示	Rabbit polyclonal serum containing 0.05% sodium azide.

应用
应用	Anti-NR2A Antibody detects level of NR2A & has been published & validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	GST-tagged recombinant protein corresponding to rat NR2A at the C-terminus.
表位	C-terminus
宿主	Rabbit
特异性	This antibody recognizes NR2A at the C-terminus.
品种反应性	RatMouse
Species Reactivity Note	Demonstrated to react with mouse and rat.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_036705
Entrez基因汇总	May play a role in synaptic transmission, learning and memory [RGD].
基因符号	NR2A GRIN2A hNR2A Glutamate NMDAR2A
纯化方法	Unpurified
UniProt编号	Q00959
UniProt汇总	FUNCTION: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. SUBUNIT STRUCTURE: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with AIP1. Found in a complex with GRIN1 and GRIN3B. Interacts with HIP1 and NETO1 By similarity. Interacts with PDZ domains of INADL and DLG4. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein SEQUENCE SIMLARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. (View classification)

产品使用声明
质量保证	Evaluated by Western Blot in mouse brain tissue lysate. Western Blot Analysis: 1:1,000 dilution of this antibody detected NR2A on 10 µg of mouse brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

包装信息
数量	100 µL

merck millipore,默克密理博,AB10531,Anti-NR2A Antibody

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