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重要规格表
描述 概述 "This safety-catch resin is a versatile tool for the production of C-terminal peptide acids [1], esters [1, 2] and amides [1], p-nitroanilides [3], and thioesters [4].
Following removal of the Fmoc group with piperidine, the resin can be acylated with the first residue under standard conditions. Acyl hydrazines derived from this resin are stable to TFA and piperidine, thereby providing the capability of removing protecting groups sensitive to these reagents prior to release of the target from the support. Oxidation with copper (II) acetate or NBS converts the hydrazine to a highly reactive diazene, which in the presence of water, amine, alcohol or thiol, decomposes to give the corresponding carboxylic acid, amide or ester. N-terminal or side-chain amino groups of the immobilized peptide can be used as the nucleophilic component, in which case the product is the appropriate cyclic peptide [5].
A similar support based on a sulfonylphenylhydrazine linker has also been employed in peptide synthesis [3]. For a review on the applications of this resin, see [6].
The product number for this product was previously 01-64-0377.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter ""A"", please select the option in the right hand menu ""Request a COA for Lot#s starting with A""产品目录编号 855037 品牌系列 Novabiochem®
同义词 01-64-0377 产品信息 HS代码 3903 90 90 结构配方图像 GHS安全信息 储存类别 10 - 13 其它液体及固体 WGK NWG 没有使水遭到危害 储存和货运信息 储存 于 +2°C 到 +8°C储存. 规格 规格 Colour (visual) yellowish to beige Appearance of substance (visual) beads Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF) 0,40 - 0,80 mmol/g Swelling Volume (in DMF) lot specific result The PEG-PS resin is prepared from aminomethyl (styrene -1% DVB). 100 - 200 mesh
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