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描述 概述 "N-Cyclohexylcarbodiimide,N'-methyl polystyrene [1] is an ideal tool for mediating solution phase coupling reactions. Typically, the amine and carboxylic acid are treated with a 2-3 fold excess of resin in DCM or DMF [2, 3]; a slight excess of carboxyl component over amine component is often used to help drive the reaction to completion. As excess acid and urea by-products remain attached to the resin at the end of the reaction, the product can normally be isolated pure by filtration and evaporation of the reaction mixture. Reactions can be accelerated by the addition of auxiliary nucleophiles such as HOBt; these can be removed using polyamine- or TBD-polystyrene. This resin has also been used in conjunction with DMAP to mediate ester formation [4].
The product number for this product was previously 01-64-0211.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter ""A"", please select the option in the right hand menu ""Request a COA for Lot#s starting with A""产品目录编号 855029 品牌系列 Novabiochem®
同义词 01-64-0211 参考 参考 [1] G.M Weinshenker, et al. (1988) Org. Synth., Coll. Vol. VI, 951.
[2] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
[3] K. Senton, et al. (2003) J. Comb. Chem., 5, 336.
[4] M. Cano, et al. (2002) J. Org. Chem., 67, 129.产品信息 HS代码 3903 90 90 结构配方图像 GHS安全信息 储存类别 10 - 13 其它液体及固体 WGK WGK 1 轻度的水危害 储存和货运信息 储存 于 +2°C 到 +8°C储存. 规格 规格 Colour (visual) white to yellow to beige Appearance of substance (visual) beads Loading (determined by HPLC after reaction of Z-Phe-OH with cyclohexylamine) ≥ 1,3 mmol/g Swelling Volume (in CH₂Cl₂) lot specific result The polymer matrix is copoly (styrene-2 % DVB), 200 - 400 mesh.
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