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CAS号 Hill配方 摩尔质量 150308-80-8 C₂₆H₂₅NO₅Se 510.44 g/mol 描述 概述 "Building block for the introduction of selenocysteine during Fmoc SPPS [1-3]. Selenocysteine derivatives can undergo enantiomerization during coupling and can form dehydroalanine and β-piperidinylalanine containing side products during subsequent chain elongation [3]. Therefore, activation methods, such as HBTU or PyBOP which involve the addition of a tertiary, base should be avoided for addtion of the Sec and all subsequent residues.
Cleavage and side-chain deprotection of Sec-containing peptides can be effected using tFA-m-cresol-thioanisole-EDT-water (80:5:5:5:5)[2] or TFA-water-DCM-TIS (89:5:51) at 4 °C [3]. As the Se-pMeOBzl bond is stable to TFA, these emthods result in formation of the corresponding Sev(pMeOBzl) peptide.
Peptides containing two Sec(pMeOBzl) residues can be oxidized directly to the corresponding selenocystinyl peptides by treatment with 5-10% DMSO in TFA [1-3].产品目录编号 852346 品牌系列 Novabiochem®
参考 参考 [1] T. Koide, et al. (1993) Chem. Pharm. Bull., 41, 502.
[2] T. Koide, et al. (1993) Chem. Pharm. Bull., 41, 1596.
[3] D. Besse & L. Moroder (1997) J. Peptide Sci., 3, 442.产品信息 CAS号 150308-80-8 Hill配方 C₂₆H₂₅NO₅Se Molar Mass 510.44 g/mol HS代码 2931 90 80 结构配方图像 GHS安全信息 储存类别 10 - 13 其它液体及固体 WGK WGK 3 高度的水危害 一次性 3
反应性相对较低的有机物必须被收集在第A类, 如果被卤化则在第B类, 如果为固体残留物则归在第C类.储存和货运信息 储存 于 +2°C 到 +8°C储存. 规格 规格 Colour (visual) white to yellow to beige Appearance of substance (visual) powder Identity (IR) passes test Enantiomeric purity ≥ 99.5 % (a/a) Purity (TLC(157A)) ≥ 98 % Assay (HPLC, area%) ≥ 98.0 % (a/a) Solubility (1 mmole in 2 ml DMF) clearly soluble For TLC-Systems see our General Catalog
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