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CAS号 Hill配方 摩尔质量 172611-77-7 C₃₉H₄₂N₂O₈ 666.77 g/mol 描述 概述 "Quasi-orthogonally-protected Asp derivative.
The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS or for library synthesis.
Occasionally sluggish cleavage of the aminobenzyl moiety is observed [2, 3]. In these instances, washing the support with 20% DIPEA in DMF/water (9:1) [2] or HCl in dioxane [4] has been found to be efficacious.
For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Asp(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.
To avoid aspartimide formation, it is advisable to employ an Hmb- or Dmb-protected derivative for introduction of the preceding residue.
For applications of this derivative in the synthesis of cyclic peptides, see references [5 - 7].
The product number for this product was previously 04-12-1176.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter ""A"", please select the option in the right hand menu ""Request a COA for Lot#s starting with A""产品目录编号 852079 品牌系列 Novabiochem®
同义词 04-12-1176;"N-α-Fmoc-L-aspartic acid α-4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-amino} benzyl ester 参考 参考 "[1] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 2209.
[2] S. Künzel, et al.Poster 17 presented at Solid Phase Synthesis & Combinatorial Libraries, Southampton, September 2001.
[3] K. F. Medzihradszky, et al. (2002) Lett. Pept. Sci., 8, 1.
[4] Albericio, et al.Poster 44 presented at American Peptide Symposium, San Diego 2005..
[5] M. Cudic, et al. in "Peptides 2000, Proc. 26th European Peptide Symposium", J. Martinez & J.-A. Fehrentz (Eds), Paris, ?ditions EDK, 2001, pp. 203.
[6] M. Cudic, et al. (2000) Tetrahedron Lett., 41, 4527.
[7] J. P. Malkinson, et al. (2003) Org. Lett., 5, 5051."产品信息 CAS号 172611-77-7 Hill配方 C₃₉H₄₂N₂O₈ Molar Mass 666.77 g/mol HS代码 2924 29 98 结构配方图像 GHS安全信息 储存类别 10 - 13 其它液体及固体 WGK WGK 2 水危害 储存和货运信息 储存 "-20 °C 规格 规格 Colour (visual) white to slight yellow to beige Appearance of substance (visual) powder Identity (IR) passes test Enantiomeric purity ≥ 99.0 % (a/a) Purity (TLC(157A)) ≥ 97 % Purity (TLC(CMA2)) ≥ 97 % Assay (HPLC, area%) ≥ 95.0 % (a/a) Solubility (1 mmole in 2 ml DMF) clearly soluble Water (K. F.) ≤ 1.0 % For TLC-Systems see our General Catalog
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