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CAS号 Hill配方 摩尔质量 893413-42-8 C₁₈H₂₇ClF₆N₆OP₂ 554.84 g/mol 描述 概述 PyClocK is the 6-chloro analog of PyBOP. Reaction of protected amino acids with PyClocK in the presence of base generates the corresponding 6-chloro-1-benzotriazolyl (Cl-OBt) ester. These active esters are considerably more reactive than those produced when using PyBOP or HBTU, owing to 6-chloro-1-hydroxybenzotriazole (Cl-HOBt) being more acidic than HOBt.
PyClocK is an excellent coupling reagent for situations where carboxyl activation may be sluggish, such as cyclizations and fragment condensations, as unlike imminium-based reagents such as HBTU and HATU excess PyClocK cannot cause end-capping of peptide chains.产品目录编号 851087 品牌系列 Novabiochem®
产品信息 CAS号 893413-42-8 Hill配方 C₁₈H₂₇ClF₆N₆OP₂ Molar Mass 554.84 g/mol HS代码 2933 99 80 理化信息 熔点 165 - 175 °C GHS安全信息 储存类别 10 - 13 其它液体及固体 WGK WGK 3 高度的水危害 储存和货运信息 储存 于 +2°C 到 +8°C储存. 规格 规格 Colour (visual) white to slight yellow to beige Appearance of substance (visual) powder Identity (IR) conforms Assay (HPLC, area%) ≥ 98,0 Area % Solubility (5% in NMP (1-Methyl-2-pyrrolidone)) clear
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