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经验配方 CAS号 C₁₃H₁₃N₅O₂ 37762-06-4 描述 概述 A cell-permeable, selective inhibitor of cGMP-specific phosphodiesterase (PDE V; IC50 = 450 nM). Inhibits PDE IX at higher concentration (IC50 = 35 µM). Also known to increase cGMP levels in spontaneously hypertensive rat (SHR) plasma and reverse nitroglycerin tolerance in vitro. Enhances the vasodilatory effects of nitric oxide. 产品目录编号 684500 品牌系列 Calbiochem®
同义词 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, M&B22948 参考 参考 Fisher, D.A., et al. 1998. J. Biol. Chem. 273, 15559.
Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med. 152, 1605.
Dundore, R.L., et al. 1993. Eur. J. Pharmacol. 249, 293.
Pagani, E.D., et al. 1993. Eur. J. Pharmacol. 243, 141.
Burns, F., et al. 1992. Biochem. J. 283, 487.
Lugnier, C., et al. 1992. Am. J. Physiol. 262, H654.产品信息 CAS号 37762-06-4 具有ATP竞争性 N 形式 White solid Hill配方 C₁₃H₁₃N₅O₂ 化学配方 C₁₃H₁₃N₅O₂ Molar Mass 271.3 可逆 N 结构配方图像 生物信息 主靶 cGMP-specific phosphodiesterase 主靶IC50 450 nM 纯度 ≥98% by TLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +15°C to +30°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
From Catalog:
Desc. Field- added "cell-permeable
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