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merck millipore,默克密理博,565725,SecinH3 - CAS 853625-60-2 - Calbiochem
产品名称：SecinH3 - CAS 853625-60-2 - Calbiochem
产品型号：565725
A cell-permeable triazolo compound that acts as a Sec7 domain-binding, selective antagonist against cytohesin family small GEFs.
merck millipore,默克密理博,565725,SecinH3 - CAS 853625-60-2 - Calbiochem
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重要规格表
经验配方 CAS号 C₂₄H₂₀N₄O₄S 853625-60-2 描述 概述 A cell-permeable triazolo compound that acts as a Sec7 domain-binding (Kd ≤250 nM for Sec7 from human cytohesins 1-3), selective antagonist against cytohesin family small GEFs (IC50 ≤5.6 µM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues). It inhibits large GEFs only at much higher concentrations (IC50 ≥65 µM in GDP/GTP exchange assays using hEFA6-S7 and yGea2-S7) and exhibits little activity against a panel of 10 commonly studied kinases or hSosII. Shown to effectively inhibit insulin signaling both in HepG2 cells in vitro and in Drosophila and mice in vivo. 产品目录编号 565725 品牌系列 Calbiochem®
同义词 N-(4-(5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide, Cytohesin Inhibitor I 参考 参考 Hafner, M., et al. 2006. Nature 444, 941.
Fuss, B., et al. 2006. Nature 444, 945.产品信息 CAS号 853625-60-2 具有ATP竞争性 N 形式 White solid Hill配方 C₂₄H₂₀N₄O₄S 化学配方 C₂₄H₂₀N₄O₄S Molar Mass 460.5 可逆 N 结构配方图像 生物信息 主靶 Cytohesin 主靶IC50 Kd ≤250 nM for Sec7 from human cytohesins 1-3; IC50 ≤5.6 µM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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