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描述 概述 Recombinant, human procathepsin V (amino acids 18-334) fused at the N-terminus to a CD33 signal sequence (amino acids 1-16) and at the C-terminus to a His•Tag® sequence and expressed in NSO cells. Cat V is predominantly expressed in normal thymus, testis, and corneal epithelium. It is involved in the invariant chain degradation in thymic epithelial cells and its overexpression has been detected in myasthenia gravis. Abnormally wide spread expressions in mammary gland and colon have also been reported in breast and colonrectal carcinomas. Although it shows high amino acid identity with cathepsin L (Cat. No. 219382), these two cathepsins have very different tissue distribution and substrate specificity. As a result of glycosylation, this recombinant enzyme migrates ~40 kDa on SDS-PAGE under either reducing or non-reducing conditions. Requires activation prior to use. 产品目录编号 219467 品牌系列 Calbiochem®
同义词 Cathepsin L2, Cathepsin U 参考 参考 Tolosa, E., et al. 2003. J. Clin. Invest. 112, 517.
Turk, V., et al. 2001. EMBO J. 20, 4629.
Somoza, J.R., et al. 2000. Biochemistry 39, 12543.
Bromme, D., et al. 1999. Biochemistry 38, 2377.
Adachi, W., et al. 1998. Invest. Ophthalmol. Vis. Sci. 39, 1789.
Santamaria, I., et al. 1998. Cancer Res. 58, 1624.产品信息 EC号 3.4.22.43 形式 Frozen liquid 配方 In 800 mM NaCl, 25 mM sodium acetate, 0.8 M NaCl, pH 5.0. Molar Mass 38700 生物信息 纯度 ≥95% by SDS-PAGE 特异活性 ≥300 units/µg 浓缩标签 Please refer to vial label for lot-specific concentration
理化信息 污染物 Endotoxins: ≤1.0 EU/µg Cathepsin V 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 To activate rhCathepsin V, pre-incubate it at 20 µg/ml in 25 mM NaOAc, 100 mM NaCl, 5 mM DTT, pH 5.5 at room temperature. Following initial thaw aliquot and freeze (-70°C).
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