- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
Uni Prot编号 P36507, Q02750 描述 产品目录编号 19-147 品牌系列 Upstate
商名 - Upstate
描述 U0126 产品信息 演示 C18H16N6S2 应用 主要应用 - Kinase Assay
应用说明 Selective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4. 生物信息 Entrez基因编号 - NM_002755.2
Entrez基因汇总 The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. 基因符号 - MKK1
- MAP2K1
- MAPKK1
- PRKMK1
- MEK1
UniProt编号 - P36507
- Q02750
UniProt汇总 FUNCTION: SwissProt: Q02750 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
SIZE: 393 amino acids; 43439 Da
SUBUNIT: Interacts with MORG1 (By similarity). Interacts with Yersinia yopJ.
PTM: Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity. & Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
DISEASE: SwissProt: Q02750 # Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
SIMILARITY: SwissProt: Q02750 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 1 mg
上一件merck millipore产品：merck millipore,默克密理博,MABD69,Anti-Novel hES cell marker DA9 Antibody, clone DA9-D9
下一件merck millipore产品：merck millipore,默克密理博,MAB5512,Anti-Parkin Antibody, clone PRK8
相关产品
merck millipore,默克密理博,ABC41,Anti-Mitofusin-1 Antibody
merck millipore,默克密理博,609310,Thyroglobulin, Bovine Thyroid Gland
merck millipore,默克密理博,17-10451,CpGenome Direct Prep Bisulfite Modification Kit (50 Reactions)
merck millipore,默克密理博,05-631,Anti-IKKγ Antibody
merck millipore,默克密理博,MABD69,Anti-Novel hES cell marker DA9 Antibody, clone DA9-D9
merck millipore,默克密理博,MAB5512,Anti-Parkin Antibody, clone PRK8
merck millipore,默克密理博,SF-1599,IL1RL2; Human, Cyanine 3 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,MABN661,Anti-QKI-5 Antibody, clone N195A/16
merck millipore,默克密理博,SF-2397,ACTA1; Human, Cyanine 3 RNA Detection Probe,SmartFlare