merck millipore,默克密理愽
  • merck millipore,默克密理博,14-703,Cot1 Protein, active, 10 µg

  • merck millipore,默克密理博,14-703,Cot1 Protein, active, 10 µg

    产品名称：Cot1 Protein, active, 10 µg
    产品型号：14-703
    Active, N-terminal 6His-tagged recombinant human Cot1, amino acids 30-397. For use in Kinase Assays.

    merck millipore,默克密理博,14-703,Cot1 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-703,Cot1 Protein, active, 10 µg

    描述
    产品目录编号 14-703
    品牌系列 Upstate
    商名
    • Upstate
    描述 Cot1 Protein, active, 10 µg
    概述 N-terminal 6His-tagged recombinant human Cot1, amino acids 30-397.
    应用
    应用 Active, N-terminal 6His-tagged recombinant human Cot1, amino acids 30-397. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Human Cot1, amino acids 30-397, expressed by baculovirus in Sf21 insect cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_005204.2
    Entrez基因汇总 This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.
    基因符号
    • Tpl-2
    • MAP3K8
    • TPL2
    • FLJ10486
    • C-COT
    • COT
    • c-COT
    • ESTF
    • EST
    蛋白靶 Cot1
    纯化方法 Ni2+/NTA-agarose
    靶子系列 STE
    UniProt编号
    • P41279
    UniProt汇总 FUNCTION: SwissProt: P41279 # Able to activate NF-kappa-B 1 by stimulating proteasome- mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form of cot has some transforming activity, although it is much weaker than the activated cot oncoprotein.
    SIZE: 467 amino acids; 52925 Da
    SUBUNIT: Interacts with NFKB1/p105.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Expressed in several normal tissues and human tumor-derived cell lines.
    DEVELOPMENTAL STAGE: The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle.
    PTM: Autophosphorylated. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.
    SIMILARITY: SwissProt: P41279 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by activation of MEK1 (14-420). The activated MEK1 was used to activate MAPKinase 2/Erk2, unactive. Subsequent phosphorylation of MBP (13-104) was performed.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C from date of shipment
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-703,Cot1 Protein, active, 10 µg

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