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纯度 ≥95% by SDS-PAGE 描述 概述 Recombinant, human activin A (disulfide-linked homodimer of two 116-amino acid residue βA subunits) expressed in CHO cells. Mature βA-monomer lacks a potential N-linked glycosylation site and has a calculated molecular weight of 13 kDa. A member of the TGF-β superfamily that is involved in the negative regulation of B lineage lymphocytes. Shown to play an important role in the regulation of hormonogenesis, cellular homeostasis, and differentiation programs. Reported to inhibit endogenous production of IL-6. 产品目录编号 114700 品牌系列 Calbiochem®
参考 参考 Zipori, D., et al. 2001. J. Leukoc. Biol. 69, 867.
Hedger, M.P., et al. 2000. Cytokine 12, 595.
Woodruff, T.K. 1998. Biochem. Pharmacol. 55, 953.
Ying, S.Y., et al. 1997. Proc. Soc. Exp. Biol. Med. 214, 114.
Schwall, R.H., and Lei, C. 1991. Methods Enzymol. 198, 340.
Mason, A., et al. 1986. Biochem. Biophys. Res. Commun. 135, 957.产品信息 形式 Lyophilized 配方 Lyophilized from sterile filtered 35% acetonitrile, 0.1% TFA, 50 µg BSA/µg Activin A. Molar Mass 26000 生物信息 生物活性 ED₅₀ = 0.5-2.0 ng/ml as measured by its ability to induce hemoglobin expression in K562 cells 纯度 ≥95% by SDS-PAGE 理化信息 污染物 Endotoxin: ≤100 pg/µg Activin A 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 ≤ -70°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
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