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Replacement Information Replacement Information Recommended replacement for AB3243 重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M WB, IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 07-696 Replaces AB3243 品牌系列 Upstate
商名 - Upstate
描述 Anti-PDX1 Antibody 背景信息 Pancreatic and duodenal homeobox 1, also known as PDX1, is a human gene. Insulin promoter factor 1 is an islet-specific protein that activates transcription of the insulin andsomatostatin genes. It is a key regulator of islet peptide hormone expressionn and also plays an essential role in pancreatic development. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus. 产品信息 格式 Serum 控制 - Mouse pancreatic beta T cell lysate
演示 UnPurified whole rabbit antiSerum containing 30% glycerol and 0.035% sodium azide. 应用 应用 Detect PDX1 with Anti-PDX1 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in ChIP, IHC, IP & WB. 主要应用 - Western Blotting
- Immunohistochemistry
生物信息 免疫原品种 GST fusion protein corresponding to residues 204-284 of mouse PDX1/IPF1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes PDX1. 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000209.2
Entrez基因汇总 Insulin promoter factor 1 is an islet-specific protein that activates transcription of the insulin andsomatostatin genes. It is a key regulator of islet peptide hormone expressionn and also plays an essential role in pancreatic development. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus. 基因符号 - IUF1
- PDX1
- IPF-1
- STF-1
- MODY4
- IPF1
- IDX-1
- PDX-1
- IUF-1
- GSF
纯化方法 Unpurified UniProt编号 - P52945
UniProt汇总 FUNCTION: SwissProt: P52945 # Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
SIZE: 283 amino acids; 30771 Da
SUBUNIT: Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).
DOMAIN: SwissProt: P52945 The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter (By similarity). & The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein- protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y) (By similarity).
PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.
DISEASE: SwissProt: P52945 # Defects in PDX1 are a cause of pancreatic agenesis [MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein and results in a second initiation that produces a second protein that act as a dominant negative mutant. & Defects in PDX1 are the cause of maturity onset diabetes noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type II. & Defects in PDX1 are the cause of maturity onset diabetes of the young type 4 (MODY4) [MIM:606392]; also symbolized MODY-4. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion.
SIMILARITY: Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. & Contains 1 homeobox DNA-binding domain.产品使用声明 质量保证 routinely evaluated by immunoblot on lysates from mouse pancreatic beta T cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µL
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