- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-748 品牌系列 Upstate
商名 - Upstate
描述 Anti-JNK/SAPK1 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect JNK/SAPK1 using this Anti-JNK/SAPK1 Antibody validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST fusion protein corresponding to full-length rat SAPK1α 宿主 Rabbit 特异性 JNK/SAPK1a; weakly recognizes JNK/SAPK1b and JNK/SAPK1c 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_139049
Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. 基因符号 - JNK
- MAPK8
- PRKM8
- JNK1A2
- JNK21B1/2
- JNK-46
- SAPK1
- JNK1
纯化方法 Protein A chromatography UniProt编号 - P45983
UniProt汇总 FUNCTION: SwissProt: P45983 # JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
COFACTOR: Magnesium.
SIZE: 427 amino acids; 48296 Da
SUBUNIT: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP (By similarity).
DOMAIN: SwissProt: P45983 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from human A431, murine 3T3 or rat PC-12 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,40-012,Luminex 200™ System
下一件merck millipore产品：merck millipore,默克密理博,HCVD1MAG-67K,MILLIPLEX MAP Human Cardiovascular Disease (CVD) Magnetic Bead Panel 1 - Cardiovascular Disease Multiplex Assay
相关产品
merck millipore,默克密理博,407241,Insulin Degrading Enzyme, His•Tag, Rat, Recombinant, S. frugiperda
merck millipore,默克密理博,AB9732,Anti-14-3-3 ε Antibody, CT
merck millipore,默克密理博,05-23-2402,Calcitonin, Human
merck millipore,默克密理博,AB9652,Anti-Tau phospho Serine 199 Antibody
merck millipore,默克密理博,40-012,Luminex 200™ System
merck millipore,默克密理博,12-338,Wortmannin, (PI3 Kinase inhibitor)
merck millipore,默克密理博,AB15299,Anti-Dendrin Antibody
merck millipore,默克密理博,07-007,Anti-phospho-BRCA1 (Ser1497) Antibody