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merck millipore,默克密理博,06-502,Anti-STAT2 Antibody, CT
产品名称：Anti-STAT2 Antibody, CT
产品型号：06-502
Anti-STAT2 Antibody, CT is a Rabbit Polyclonal Antibody for detection of STAT2 also known as Signal Transducer & Activator of Transcription 2 & has been tested in EMSA, IP, WB, ICC.
merck millipore,默克密理博,06-502,Anti-STAT2 Antibody, CT
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, EMSA, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-502 品牌系列 Upstate
商名 - Upstate
描述 Anti-STAT2 Antibody, CT 产品信息 格式 Purified 演示 0.07 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide and 30% glycerol. 应用 应用 Anti-STAT2 Antibody, CT is a Rabbit Polyclonal Antibody for detection of STAT2 also known as Signal Transducer & Activator of Transcription 2 & has been tested in EMSA, IP, WB, ICC. 主要应用 - Immunocytochemistry
- Electrophoretic Mobility Shift Assay
- Western Blotting
生物信息 免疫原品种 GST fusion protein containing amino acids 671-806 of human STAT2 宿主 Rabbit 特异性 STAT2 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005419
Entrez基因汇总 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. 基因符号 - MGC59816
- STAT2
- ISGF-3
- P113
- p113
- STAT113
纯化方法 Protein A chromatography UniProt编号 - P52630
UniProt汇总 FUNCTION: SwissProt: P52630 # Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
SIZE: 851 amino acids; 97916 Da
SUBUNIT: Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
PTM: Tyrosine phosphorylated in response to IFN-alpha.
SIMILARITY: SwissProt: P52630 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.产品使用声明 质量保证 Immunoblot Analysis: 0.5-2 μg/ml of this antibody detected STAT2 (113kDa) in Jurkat cell lysates. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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