merck millipore,默克密理愽
  • merck millipore,默克密理博,04-575,Anti-PARP-1 (p116/p25) Antibody, rabbit monoclonal

  • merck millipore,默克密理博,04-575,Anti-PARP-1 (p116/p25) Antibody, rabbit monoclonal

    产品名称：Anti-PARP-1 (p116/p25) Antibody, rabbit monoclonal
    产品型号：04-575
    Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-PARP-1 (p116/p25) Antibody detects level of PAR More>>

    merck millipore,默克密理博,04-575,Anti-PARP-1 (p116/p25) Antibody, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-575,Anti-PARP-1 (p116/p25) Antibody, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-575
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-PARP-1 (p116/p25) Antibody, rabbit monoclonal
    Alternate Names
    • ARTD1
    • poly (ADP-ribose) polymerase-1
    背景信息 Poly (ADP-ribose) polymerase (PARP) is zinc-dependent DNA binding protein that recognizes DNA strand breaks and is presumed to play a role in DNA repair (1). As a marker for apoptosis, PARP is cleaved in vitro by many caspases, and in vivo by Caspase-3 (2,3). Existing as a 116 kDa nuclear protein, PARP is cleaved between amino acids Asp214 and Gly215 to yield two fragments of 29 kDa (C-terminal catalytic domain) and 85 kDa (N-terminal DNA-binding domain) (2,4).
    产品信息
    格式 Purified
    演示 Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
    应用
    应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-PARP-1 (p116/p25) Antibody detects level of PARP-1 (p116/p25) & has been published & validated for use in IP & WB.
    主要应用
    • Western Blotting
    应用说明 WB: 1:1000 IP: 1:80
    生物信息
    免疫原品种 A synthetic peptide corresponding to residues before the cleavage site of human PARP-1. The antibody only recognizes full-length form (p116) of PARP-1.
    克隆 Y17
    宿主 Rabbit
    特异性 Recognizes Human PARP-1 (p116/p25).
    品种反应性 Human
    Species Reactivity Note Human (positive control: Jurkat cell lysate)
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001618.2
    Entrez基因汇总 This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
    基因符号
    • poly(ADP-ribosyl)transferase
    • PARP-1
    • PARP
    • pADPRT-1
    • ADPRT1
    • ADPRT
    • PARP1
    • NAD
    • Poly
    • PPOL
    UniProt编号
    • P09874
    UniProt汇总 FUNCTION: SwissProt: P09874 # Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
    SIZE: 1014 amino acids; 113084 Da
    SUBUNIT: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with ZNF423 (By similarity).
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR. & Poly-ADP-ribosylated by PARP2.
    SIMILARITY: SwissProt: P09874 ## Contains 1 BRCT domain. & Contains 1 PARP alpha-helical domain. & Contains 1 PARP catalytic domain. & Contains 2 PARP-type zinc fingers.
    MISCELLANEOUS: The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -20 °C. Stable for 12 months from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-575,Anti-PARP-1 (p116/p25) Antibody, rabbit monoclonal

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